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目的探讨腹腔镜保守手术后应用曼月乐以及GnRHa联合治疗子宫内膜异位症的疗效。方法 40例EMs患者随机分配到对照组和观察组,各20例。对照组接受GnRHa治疗,观察组接受GnRHa和曼月乐联合治疗,通过观察两组患者的疼痛程度、CA125水平来评定治疗效果。结果对照组与观察组中,术后半年、术后1年的VAS评分低于手术前(P<0.05);对照组术后1年的VAS评分高于观察组(P<0.05)。对照组与观察组中,术后半年、术后1年的CA125水平低于手术前(P<0.05);对照组术后1年的CA125水平高于观察组(P<0.05)。结论曼月乐和GnRHa联合治疗EMs的效果显著,可长时间缓解患者的疼痛,值得推广。
Objective To investigate the efficacy of laparoscopic conservative surgery combined with Mirena and GnRHa in the treatment of endometriosis. Methods Forty patients with EMs were randomly assigned to control group and observation group, with 20 cases in each group. Control group received GnRHa treatment, the observation group received GnRHa and Mirena combination therapy, by observing the two groups of patients with pain levels, CA125 levels to evaluate the therapeutic effect. Results The VAS scores of the control group and the observation group were lower than those before surgery (P <0.05). The VAS score of the control group was significantly higher than that of the observation group at one year after operation (P <0.05). The levels of CA125 in control group and observation group were lower than those before operation (P <0.05) at 6 months and 1 year after operation. The CA125 level at 1 year after operation in control group was higher than that in observation group (P <0.05). Conclusion The combined effect of Mirena and GnRHa in the treatment of EMs is significant. It can prolong the pain of patients and is worth promoting.