As one type of promising candidates for environmental and energy-related systems,multi-shelled transition metal oxide hollow structures(MS-TMOHSs) have drawn great scientific and technical interest in the past few years.This article highlights recent advances in one-pot solution synthesis of MSTMOHSs. We begin it with an overview of synthetic strategies that have been exploited to achieve these peculiar structures.We then focus on one-pot solution approaches in the following four sections:i) soft templates directed growth;ii) Ostwald ripening;iii) controlled etching;and iv) gas bubble assisted growth.After giving a brief discussion on the unique properties and applications of these multi-shelled hollow structures,we conclude this review with the general challenges and the potential future directions of this exciting area of research. As one type of promising candidates for environmental and energy-related systems, multi-shelled transition metal oxide hollow structures (MS-TMOHSs) have drawn great scientific and technical interest in the past few years. This article highlights recent advances in one-pot solution synthesis of MSTMOHSs. We begin it with an overview of synthetic strategies that have been exploited to achieve these peculiar structures. We then focus on one-pot solution approaches in the following four sections: i) soft templates directed growth; ii) Ostwald ripening; iii) controlled etching; and iv) gas bubble assisted growth. After giving a brief discussion on the unique properties and applications of these multi-shelled hollow structures, we conclude this review with the general challenges and the potential future directions of this exciting area of research.