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本文采用冷冻保存人胎胰岛细胞对11例IDDM患者(男7,女4;年龄22～41岁,病程2～10年)进行移植。随机分腹腔移植5例;三角肌移植6例。平均移植胎胰数为10.45±0.93个(10～13个)。移植过程未用免疫抑制剂。于移植前和移植后1、2、6个月,分别对临床症状、血糖、HbA_1、24小时尿糖、C肽、肌酐清除率(Ccr)、OK_(T4)、OK_(T8)以及每日胰岛素需要量等进行了评价。结果显示移植后代谢指标无改善,胰岛素需要量未明显减少。未达予期效果。因此认为冷冻保存人胎胰岛细胞在体外活性与临床疗效之间存在矛盾,其原因有待进一步阐明。
In this paper, cryopreserved human fetal islet cells in 11 cases of IDDM patients (male 7, female 4; aged 22 to 41 years, duration of 2 to 10 years) transplantation. Randomly divided abdominal transplants in 5 cases; deltoid muscle transplantation in 6 cases. The average number of transplanted fetal pancreas was 10.45 ± 0.93 (10 ~ 13). Immune inhibitors were not used during the transplantation. Clinical symptoms, blood glucose, HbA_1, 24-hour urine glucose, C-peptide, creatinine clearance rate (Ccr), OK_ (T4), OK_ (T8) and daily Insulin requirements were evaluated. The results showed no improvement in metabolic indicators after transplantation, insulin requirement was not significantly reduced. Did not reach the period effect. Therefore, there is a contradiction between the activity of cryopreserved human fetal islet cells in vitro and clinical efficacy, the reason needs to be further elucidated.