【摘 要】
：
Twenty-two new limonoids,mufolinoids A-V (1-22),including six rings A,B-seco limonoids (1-6),twelve ring A-seco limonoids(7-18),four ring-intact limonoids (19-22),together with thirteen known compounds (23-35) were isolated from Munronia unifo-liolata.The
【机 构】
：
Jiangsu Key Laboratory of Bioactive Natural Product Research,State Key Laboratory of Natural Medicin
论文部分内容阅读
Twenty-two new limonoids,mufolinoids A-V (1-22),including six rings A,B-seco limonoids (1-6),twelve ring A-seco limonoids(7-18),four ring-intact limonoids (19-22),together with thirteen known compounds (23-35) were isolated from Munronia unifo-liolata.Their structures including absolute configurations were elucidated by combination of NMR,HR-MS,single-crystal X-ray dif-fraction and calculations of ECD and NMR technologies.Compounds 24,25,33,34 could be significantly reversed the multidrug re-sistance of MCF-7/doxorubicin (DOX) cells,and the reversal fold (RF) was much higher than that of positive drug Verapamil.Com-pounds 24,28,and 29 exhibited significant anti-inflammatory activity with the ICs0 values in the range of 17.7-39.4 μmol/L.Fur-thermore,compound 29 could markedly inhibit the release of IL-1β by inhibiting the initiation and assembly of NLRP3 inflam-masome,which demonstrates the great potential of limonoids as an anti-inflammatory agent.
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