论文部分内容阅读
目的研究2型糖尿病与甲状腺结节之间的关系,探讨影响甲状腺结节的危险因素,为预防甲状腺结节的发生提供参考。方法构建多中心健康查体人群队列,体检者进入队列时均无甲状腺结节,共有15 528人进入随访队列,应用广义估计方程(GEE)模型研究2型糖尿病与甲状腺结节之间的关联。结果2010年结束随访时共检出甲状腺结节患者1 592人,2型糖尿病组和健康体检组发病密度分别为36.33/1 000人年和28.55/1 000人年,两组之间差异有统计学意义(χ2=14.80,P<0.001)。在控制了其他潜在的混杂因素后,多因素GEE模型发现2型糖尿病与甲状腺结节之间具有关联性(RR=1.299,P=0.001)。结论2型糖尿病是甲状腺结节的独立危险因素。
Objective To study the relationship between type 2 diabetes mellitus and thyroid nodules, to explore the risk factors affecting thyroid nodules and to provide references for the prevention of thyroid nodules. Methods Constructing a cohort of multicentral health checkups with no thyroid nodules when entering the cohort. A total of 15 528 people were included in the follow-up cohort. The association between type 2 diabetes mellitus and thyroid nodules was studied using the generalized estimation equation (GEE) model. Results A total of 1 592 thyroid nodules were detected at the end of follow-up in 2010, with an incidence of 36.33 / 1000 and 28.55 / 1000 person-years respectively in type 2 diabetes and healthy subjects, with statistical differences between the two groups Significance (χ2 = 14.80, P <0.001). After controlling for other potential confounders, the multifactorial GEE model found a link between type 2 diabetes and thyroid nodules (RR = 1.299, P = 0.001). Conclusion Type 2 diabetes is an independent risk factor for thyroid nodules.