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目的探讨地诺前列酮栓(欣普贝生)用于足月妊娠胎膜早破的引产时机。方法足月妊娠胎膜早破患者134例,随机分为观察组和对照组,每组67例,观察组于破水后6 h放置欣普贝生,对照组破水期24 h后评估宫颈评分<6分再放置欣普贝生,观察两组患者的剖宫产率、临产时间、总产程、胎儿窘迫、新生儿窒息、产褥感染率等临床指标。结果观察组放药后至临产时间及临产至分娩时间分别为(380.8±215.2)min、(365.5±180.3)min,对照组放药后至临产时间及临产至分娩时间分别为(420.6±165.8)min、(410.5±198.6)min,两组放药后至临产时间及临产至分娩时间差异无统计学意义(P>0.05)。观察组产褥感染发生1例,对照组产褥感染发生2例,观察组胎儿窘迫发生3例,对照组胎儿窘迫发生4例,两组均没有出现新生儿窒息发生,观察组与对照组在产褥感染、新生儿窘迫发生率及新生儿窒息方面差异无统计学意义(P>0.05)。观察组患者67例,阴道分娩62例,剖宫产5例,剖宫产率为7.5%,对照组患者中有6例患者由于产程缓慢失去信心剖宫产,共15例患者剖宫产,剖宫产率为22.4%,观察组患者剖宫产率明显低于对照组(P<0.05)。结论欣普贝生用于足月胎膜早破促宫颈成熟安全有效,可以降低剖宫产率,值得临床推广。
Objective To investigate the timing of induction of labor with pregame propranolol suppository (Xin P bei sheng) in term pregnancy with premature rupture of membranes. Methods 134 cases of premature rupture of membranes in full-term pregnancy were randomly divided into observation group and control group, 67 cases in each group. The observation group was placed in Hinbu Beisin 6 h after water break, 6 points and then placed Hippocampus, observed two groups of patients with cesarean section rate, duration of labor, total labor, fetal distress, neonatal asphyxia, puerperal infection rate and other clinical indicators. Results The time from labor to labor and delivery to delivery in the observation group were (380.8 ± 215.2) min and (365.5 ± 180.3) min, respectively. The time from the delivery to labor and the time from labor to delivery in the control group were (420.6 ± 165.8) min and (410.5 ± 198.6) min, respectively. There was no significant difference between the two groups after the drug was given to labor and the time between labor and labor. (P> 0.05). One case of puerperal infection occurred in observation group, 2 cases of puerperal infection in control group, 3 cases of fetal distress in observation group, 4 cases of fetal distress in control group, no neonatal asphyxia occurred in both groups, The incidence of puerperal infection, neonatal distress and neonatal asphyxia had no significant difference (P> 0.05). 67 patients in the observation group, vaginal delivery in 62 cases, 5 cases of cesarean section, cesarean section rate of 7.5%, 6 patients in the control group due to slow labor loss of confidence cesarean section, a total of 15 patients with cesarean section, The cesarean section rate was 22.4%. The cesarean section rate in the observation group was significantly lower than that in the control group (P <0.05). Conclusion The application of Enopbei for full-term premature rupture of membranes to promote cervical ripening is safe and effective, which can reduce the rate of cesarean section, worthy of clinical promotion.