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目的探索防氟改水对氟中毒患者脂质过氧化和抗氧化水平的影响。方法采用横断面调查法对改水２３年、改水一年和未改水氟中毒病区的氟中毒患者（３５～５５岁）和非病区健康者各１６人进行研究。结果改水２３年平均尿氟水平明显低于未改水组，与非病区对照组无明显差异。改水一年组尿氟水平明显低于未改水组，但明显高于非病区对照组。改水２３年组全血ＧＳＨ平均含量和ＧＳＨ－Ｐｘ平均活性明显高于未改水组和改水一年组，与非病区对照组无明显差异。改水一年组与未改水组无明显差异，未改水组明显高于非病区对照组。不同组间血清ＳＯＤ和ＬＰＯ水平无明显差异。结论长期饮用高氟水能降低机体抗氧化物质ＧＳＨ含量和ＧＳＨ－Ｐｘ的活性，当机体氟负荷降低并稳定一段时间后能恢复至正常水平
Objective To explore the effect of anti-fluoride and water on lipid peroxidation and anti-oxidation in patients with fluorosis. Methods A cross-sectional study was conducted to investigate the effects of water-changing for 23 years, water-changing for one year and fluorine-poisoning patients (35-55 years old) who had not changed water fluorosis area and 16 persons each other who were non-ward healthy. Results The 23-year average urinary fluoride level after water changing was significantly lower than that of the non-water-changing group and no significant difference with non-ward control group. In the year of water reform, the level of urinary fluoride was significantly lower than that of the group without water change, but significantly higher than that of the non-ward control group. The average GSH-Px level and the average GSH-Px activity in the whole blood of the 23-year water improvement group were significantly higher than those in the non-water-deficient group and the water-reforming group, with no significant difference from the non-ward control group. There was no significant difference between the water-changing year group and the non-water-changing group, and the water-changing group was significantly higher than the non-ward control group. There was no significant difference in serum SOD and LPO between different groups. Conclusion Long-term drinking of high fluoride water can reduce the body’s antioxidant GSH content and GSH-Px activity, when the body of fluoride load decreased and stable for a period of time can return to normal levels