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目的:比较分析丁苯酞和脑活素添加治疗急性缺血性脑卒中的近期临床疗效。方法:急性缺血性脑卒中患者60例随机分成3组,每组20例。丁苯酞治疗组:添加丁苯酞软胶囊200mg,口服,每日3次,疗程10d。脑活素治疗组:添加脑活素30mL,静脉滴注,每日1次,疗程10d。对照组:采用常规基础脑卒中治疗,不再添加任何药物。采用NIHSS评分和日常生活活动量表Barthel指数(BI)评价治疗后第11、21天神经功能恢复情况。结果:丁苯酞添加组在治疗后第21天NIHSS评分和BI评分与对照组比较,差异有统计学意义(均P<0.05);两组患者NIHSS评分和BI评分的改善分值,在治疗后第11、21天均显著高于对照组(P<0.05),两组21dNIHSS评分改善分值比较差异有统计学意义(P<0.05)。结论:早期应用丁苯酞能改善急性缺血性脑卒中的神经功能缺损及日常生活能力,临床疗效显著,应用安全。
Objective: To compare the short-term clinical efficacy of butylphthalide and cerebrolysin in the treatment of acute ischemic stroke. Methods: 60 patients with acute ischemic stroke were randomly divided into 3 groups, 20 cases in each group. Butylphthalide treatment group: add butylphthalide soft capsule 200mg, orally, 3 times a day, treatment 10d. Cerebrolysin treatment group: add cerebrolysin 30mL, intravenous infusion, 1 day, treatment 10d. Control group: The treatment of conventional basis of stroke, no longer add any drugs. NIHSS score and Barthel index (BI) were used to evaluate the neurological function recovery on the 11th and 21st day after treatment. Results: NIHSS score and BI score on the 21th day after treatment in the butylphthalide group were significantly different from those in the control group (all P <0.05). NIHSS score and BI score improved scores in both groups (P <0.05) on the 11th and 21st days after operation, and there was significant difference between the two groups in improving score of 21-day NIHHS score (P <0.05). CONCLUSION: The early application of butylphthalide can improve the neurological deficits and daily living ability of patients with acute ischemic stroke. The clinical efficacy is significant and safe.