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目的观察纳络酮和醒脑静治疗Ⅱ型呼吸衰竭肺性脑病的疗效。方法将入选的50例患者随机分为治疗组和对照组。两组均予以积极的控制感染,持续低流量吸氧,解痉、平喘、化痰,保持气道通畅,呼吸兴奋剂,维持电解质及酸碱平衡,脑保护、营养支持等综合治疗。治疗组在此基础上加用纳络酮和醒脑静。结果治疗组总有效率显著高于对照组(P<0.05);动脉血氧分压(PaO2)显著高于对照组(P<0.05);动脉血二氧化碳分压(PaCO2)显著低于对照组(P<0.05);治疗过程中无不良反应。结论纳络酮联合醒脑静治疗Ⅱ型呼吸衰竭肺性脑病疗效确切、安全。
Objective To observe the curative effect of naloxone and xingnaojing on pulmonary encephalopathy in type Ⅱ respiratory failure. Methods Selected 50 patients were randomly divided into treatment group and control group. Both groups were actively controlled infection, continued low-flow oxygen, spasm, asthma, phlegm, maintain airway patency, respiratory stimulants to maintain electrolyte and acid-base balance, brain protection, nutritional support and other comprehensive treatment. On the basis of the treatment group, naloxone and xingnaojing were added. Results The total effective rate in the treatment group was significantly higher than that in the control group (P <0.05); PaO2 was significantly higher than that in the control group (P <0.05); PaCO2 in arterial blood was significantly lower than that in the control group P <0.05); no adverse reactions in the course of treatment. Conclusion Naloxone combined with xingnaojing is effective and safe in treating pulmonary encephalopathy of type Ⅱ respiratory failure.