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急性肾衰竭是一种高死亡率的临床综合征,发病机制十分复杂。近年来,越来越多的证据表明炎症及炎症介质在急性肾衰竭中起重要作用。了解炎症介质及其他免疫因子的基因多态性,对正确认识急性肾衰竭的发病机制,以及预防和治疗该病具有重要意义。本文就一些主要炎症介质、热休克蛋白的基因多态性以及与急性肾衰竭的关系作一综述。
Acute renal failure is a clinical syndrome with high mortality, the pathogenesis is very complicated. In recent years, more and more evidences indicate that inflammation and inflammatory mediators play an important role in acute renal failure. To understand the genetic polymorphisms of inflammatory mediators and other immune factors is of great importance for the correct understanding of the pathogenesis of acute renal failure and prevention and treatment of the disease. This review summarizes the genetic polymorphisms of some major inflammatory mediators, heat shock proteins and their association with acute renal failure.