霉酚酸酯(mycophenolate mofetil,MMF)是次黄嘌呤核苷酸脱氢酶的选择性抑制剂,通过抑制鸟嘌呤核苷酸的从头合成,选择性阻断T、B淋巴细胞增殖、活化。近年研究表明其具有免疫、抗炎、抗血管增殖等作用,基于这些特殊的药理作用,霉酚酸酯作为一种新型免疫抑制剂,逐渐从肾移植领域的应用拓展到各种原发性及继发性肾小球疾病的治疗中,可以减少糖皮质激素及传统免疫抑制剂用量、提高缓解率。 Mycophenolate mofetil (MMF), a selective inhibitor of inosine dehydrogenase, selectively blocks T and B lymphocyte proliferation and activation by inhibiting de novo synthesis of guanosine nucleotides. In recent years, studies have shown that it has immune, anti-inflammatory, anti-vascular proliferation and other effects, based on these special pharmacological effects, mycophenolate as a new immunosuppressive agent, gradually expanded from the field of kidney transplantation to a variety of primary and Secondary glomerular disease treatment, can reduce the amount of glucocorticoid and traditional immunosuppressive agents, improve remission rate.