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目的观察静脉丙种球蛋白对急性病毒性心肌炎心肌酶、血清TNRa及IL-4的影响及临床疗效。方法采用随机数字表法将92例患者随机分为2组即治疗与对照组,两组患者均嘱卧床休息,应用广谱抗生素,给予三磷酸腺苷,辅酶A,维生素C,维生素E,普通胰岛素,肌苷等常规治疗,合并心律失常者加用相应抗心律失常药物。治疗组在上述治疗的基础上加用静脉丙种球蛋白(蓉生静丙,2.5 g/瓶,成都生物制品研究所研制),200 mg/kg·d,连用7 d。2周后进行疗效评定。结果两组患者在临床症状及ECG明显改善,TNFa、IL-4明显降低,差异有统计学意义(P<0.05或P<0.01)。结论早期应用静脉丙种球蛋白早期干预可明显降低CK、CK-MB、LDH1、LDH2,调节免疫系统,改善临床症状。
Objective To observe the effect of intravenous gamma globulin on myocardial enzymes, serum TNRa and IL-4 in acute viral myocarditis and its clinical efficacy. Methods Ninety-two patients were randomly divided into two groups: treatment group and control group. Randomized bed rest and broad-spectrum antibiotics were given to both groups. Adenosine triphosphate, coenzyme A, vitamin C, vitamin E, normal insulin, Glycosides and other conventional treatment, combined with arrhythmia associated with anti-arrhythmic drugs. Treatment group based on the above treatment with intravenous gamma globulin (Rongsheng C, 2.5 g / bottle, Chengdu Institute of Biological Products), 200 mg / kg · d, once every 7 d. 2 weeks after the curative effect evaluation. Results The clinical symptoms and ECG of both groups were significantly improved, TNFa and IL-4 were significantly decreased, the difference was statistically significant (P <0.05 or P <0.01). Conclusion Early application of intravenous gamma globulin early intervention can significantly reduce CK, CK-MB, LDH1, LDH2, regulate the immune system and improve clinical symptoms.