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目的 研究99mTc MIBI(甲氧基乙丁基异腈 )肺显像定性检测非小细胞肺癌P 糖蛋白 (P GP)及与化疗效果对比。方法 采用二时相平面显像 ,以病灶处99mTc MIBI的潴留指数 (RI)为P GP定性指标 ,RI <0为P GP阳性 ,以WHO标准将疗效分为完全或者部分缓解 (CR、PR)无变化 (NC) ,进展 (PD) ,将P GP定性结果与疗效比较。结果 3 2例非小细胞肺癌中 2 1例 ( 6 5 .6 % )P GP表达阳性 ,化疗有效率为 9.5 % ,11例 ( 3 4.4% )P GP表达阴性 ,化疗有效率为 81.8% ,两组化疗有效率有显著性差异 (P <0 .0 1)。结论 99mTc MIBI肺显像可作为肺癌P GP非组织学测定方法 ,可预测化疗敏感性 ,指导临床治疗。
Objective To investigate the qualitative detection of P-glycoprotein (P-GP) in non-small cell lung cancer by 99mTc MIBI (methyl isobutylene isonitrile) lung imaging and compare it with the effect of chemotherapy. Methods Two-phase planar imaging was used. The retention index (RI) of the 99mTc MIBI at the lesion was used as a qualitative indicator of PGP. RI <0 was positive for PGP. The efficacy was divided into complete or partial remission with the WHO criteria (CR, PR). No change (NC), progression (PD), compared P GP qualitative results with curative effect. Results Among 22 cases of non-small cell lung cancer, 21 were positive for P GP (6.56%), the effective rate for chemotherapy was 9.5%, and 11 cases (3.4%) had negative GP expression. The effective rate of chemotherapy was 81.8%. There was a significant difference in the efficiency of chemotherapy between the two groups (P < 0.01). Conclusion 99mTc MIBI lung imaging can be used as a non-histological method for the detection of P-GP in lung cancer. It can predict chemotherapy sensitivity and guide clinical treatment.