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目的:探讨微小乳头状甲状腺癌(PTMC)合并桥本甲状腺炎(HT)患者的临床病理特征与颈淋巴结转移规律。方法:回顾性分析2008年10月—2012年10月治疗的284例PTMC患者临床资料,按是否合并HT分为研究组(n=58)与对照组(n=226),分析PTMC合并HT与临床病理因素的关系,以及PTMC患者颈淋巴结转移的影响因素。结果:58例PTMC合并HT患者中女性52例(89.7%)。单因素分析显示,性别、多发病灶、颈部侧区淋巴结转移、颈侧区合并中央区的淋巴结转移、与PTMC合并HT有关(均P<0.05);多因素分析显示,PTMC合并HT为颈侧区淋巴结转移及颈侧区合并中央区淋巴结转移的独立危险因素(均P<0.05)。结论:PTMC合并HT以女性患者多见,常为多发病灶,并出现颈侧区淋巴结连续性转移。
Objective: To investigate the clinicopathological features and cervical lymph node metastasis in patients with papillary thyroid carcinoma (PTMC) complicated with Hashimoto’s thyroiditis (HT). Methods: The clinical data of 284 PTMC patients who were treated from October 2008 to October 2012 were retrospectively analyzed. According to whether HT was divided into study group (n = 58) and control group (n = 226), PTMC combined HT and Clinical and pathological factors, as well as PTMC patients with cervical lymph node metastasis factors. Results: Fifty-eight cases of PTMC combined with HT were female (n = 52) (89.7%). Univariate analysis showed that gender, multiple lesions, lymph node metastasis in the cervical region and lymph node metastasis in the lateral cervical region were associated with PTMC combined HT (all P <0.05). Multivariate analysis showed that PTMC combined with HT Regional lymph node metastasis and cervical side area with central lymph node metastasis of independent risk factors (all P <0.05). Conclusion: PTMC combined HT is more common in female patients, often multiple lesions, and cervical lymph node metastasis.