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目的探讨克林霉素联合妇科千金胶囊治疗慢性盆腔炎(chronic pelvic inflammatory disease,CPID)的疗效及对血清C反应蛋白(C-reactive protein,CRP)的影响。方法将92例CPID患者随机分为观察组和对照组,每组各46例。观察组予克林霉素盐酸盐注射液、妇科千金胶囊治疗;对照组予青霉素钠、甲硝唑片治疗。比较两组患者疗效、临床症状积分的变化、CRP的变化及复发率。结果观察组总有效率97.83%,高于对照组73.91%(P<0.05);两组患者治疗后的临床症状积分、血清CRP均低于治疗前,且观察组降低更显著(P<0.05);观察组的复发率为4.35%,低于对照组19.57%(P<0.05)。结论克林霉素联合妇科千金胶囊可以提高对CPID的疗效,有效抑制炎症反应,迅速改善临床症状,安全性好,复发率低。
Objective To investigate the curative effect of clindamycin combined with gynecological Qianjin capsule on chronic pelvic inflammatory disease (CPID) and its effect on serum C-reactive protein (CRP). Methods 92 cases of CPID patients were randomly divided into observation group and control group, 46 cases in each group. The observation group was given clindamycin hydrochloride injection and gynecological Qianjin capsule. The control group was given penicillin sodium and metronidazole tablets. The curative effect, change of clinical symptom score, change of CRP and relapse rate were compared between the two groups. Results The total effective rate in the observation group was 97.83%, which was higher than that in the control group (73.91%, P <0.05). The clinical symptom scores and serum CRP in the two groups were lower than those before treatment and the observation group was more significant (P <0.05) ; The recurrence rate of the observation group was 4.35%, which was lower than that of the control group (19.57%, P <0.05). Conclusion Clindamycin combined with gynecological Qianjin capsule can improve the curative effect on CPID, effectively inhibit the inflammatory reaction, rapidly improve the clinical symptoms, and has good safety and low recurrence rate.