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目的：探讨减压缺氧时大鼠红细胞变形性的改变及其机制。方法：测定平原和减压缺氧条件下大鼠红细胞滤过指数（ＩＦ）、红细胞膜ＡＴＰａｓｅ活性、红细胞ＡＴＰ含量。结果：各缺氧组细胞ＩＦ均较平原组升高，缺氧１４ｄ组虽有所下降，但仍高于对照组，缺氧２１ｄ组与３０ｄ组无明显差异；缺氧１ｄ、７ｄ组ＡＴＰ含量下降，且与同期红细胞ＩＦ呈显著负相关，缺氧各组红细胞Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－ＡＴＰａｓｅ活性均有不同程度明显下降，Ｍｇ２＋－ＡＴＰａｓｅ活性仅缺氧３０ｄ组下降明显。结论：①缺氧可致红细胞变形性损害，但其发生并非进行性，大约于缺氧后３～４周达到一个较为稳定的水平；②缺氧早期红细胞ＡＴＰ含量下降，整个缺氧过程中红细胞膜ＡＴＰａｓｅ活性降低在大鼠红细胞变形性损害中起重要作用。
Objective: To investigate the alteration of erythrocyte deformability and its mechanism during hypobaric hypoxia in rats. Methods: The levels of erythrocyte filtration index (IF), erythrocyte membrane ATPase activity and erythrocyte ATP content in rats under plain and hypobaric hypoxia were measured. Results: The IF of each hypoxia group was higher than that of the plain group, although the hypoxia 14d group was decreased, but still higher than the control group, hypoxia 21d group and 30d group no significant difference; hypoxia 1d, 7d group ATP content (P <0.05), while there was a significant negative correlation with the IF of erythrocytes in the same period. The activities of Na + -K + -ATPase and Ca2 + -ATPase in erythrocytes of hypoxia group decreased significantly in different degrees, and the activity of Mg2 + -ATPase decreased significantly in hypoxia 30d group. Conclusion: ① Hypoxia can cause erythrocyte deformability damage, but its occurrence is not progressive, about 3 to 4 weeks after hypoxia to achieve a more stable level; ② hypoxia early erythrocyte ATP content decreased during the entire hypoxia red blood cells Decreased membrane ATPase activity plays an important role in the damage of rat erythrocyte deformability.