目的:对应用中药结核丸与免疫调节剂联合对患有肺结核疾病患者在接受复治期间实施辅助性治疗的临床效果进行研究。方法:选择在我中心收治的患有肺结核疾病患者48例,随机分为对照组、研究1组、研究2组,平均每组16例。采用常规抗结核治疗方案对对照组研究对象实施肺结核疾病复治;在常规抗结核治疗方案基础上,加用母牛分枝杆菌菌苗对研究1组研究对象实施肺结核疾病复治;在研究1组治疗方案基础上,加用中药结核丸对研究2组研究对象实施肺结核疾病复治。对比三组研究对象的肺结核疾病复治的治疗效果、痰菌检测结果转阴时间、检查显示病灶明显吸收时间、肺结核疾病复治计划实施总时间、在抗结核疾病治疗期间出现的药物相关不良反应人数。结果:研究2组研究对象肺结核疾病复治的治疗效果明显优于研究1组和对照组,组间差异显著(P<0.05);研究1组研究对象肺结核疾病复治的治疗效果明显优于对照组,组间差异显著(P<0.05)。研究2组研究对象的痰菌检测结果转阴时间、检查显示病灶明显吸收时间、肺结核疾病复治计划实施总时间明显短于研究1组和对照组,组间差异显著(P<0.05);研究1组研究对象的痰菌检测结果转阴时间、检查显示病灶明显吸收时间、肺结核疾病复治计划实施总时间明显短于对照组,组间差异显著(P<0.05)。研究2组研究对象在抗结核疾病治疗期间出现的药物相关不良反应人数明显少于研究1组和对照组,组间差异显著(P<0.05);研究1组研究对象在抗结核疾病治疗期间出现的药物相关不良反应人数明显少于对照组,组间差异显著(P<0.05)。研究2组外周血T细胞亚群水平在用药前后的变化情况明显好于研究1组和对照组,组间差异显著(P<0.05)。结论:应用中药结核丸与免疫调节剂联合对患有肺结核疾病患者在接受复治期间实施辅助性治疗的临床效果非常明显。 OBJECTIVE: To study the clinical effect of applying traditional Chinese medicine (TB) pill combined with immunomodulator on patients with pulmonary tuberculosis who received adjuvant therapy during retreatment. Methods: Forty-eight patients with pulmonary tuberculosis admitted to our center were randomly divided into control group, study group 1 and study group 2, with an average of 16 in each group. Conventional anti-tuberculosis treatment regimen was used to re-treat pulmonary tuberculosis in the control group. On the basis of routine anti-tuberculosis treatment, mycobacterium vaccae vaccine was used to treat re-treatment of tuberculosis in study group 1. In study 1 On the basis of group therapy, we added Chinese medicine TB pills to study the two groups of study subjects to carry out retreatment of tuberculosis. To compare the curative effect of retreatment of pulmonary tuberculosis in three groups of subjects, the time of negative results of sputum test, the time of apparent absorption of the lesions, the total time of reinstatement of tuberculosis, the drug-related adverse reactions occurred during the treatment of tuberculosis Number of people. Results: The treatment effect of treatment of pulmonary tuberculosis was significantly better than that of study 1 and control group (P <0.05), and the treatment effect of group 1 was significantly better than that of control There was significant difference between groups (P <0.05). The results showed that the sputum test results of two groups of patients turned out to be negative, the examination showed obvious absorption time of the lesions, and the total duration of the planned treatment of pulmonary tuberculosis was significantly shorter than that of the study group 1 and the control group (P <0.05) The results of sputum test in one study group turned negative. The examination showed that the time of obvious absorption of the lesions was significantly shorter than that of the control group (P <0.05). There were significant differences in the number of ADRs between the two study groups during the treatment of anti-tuberculosis disease (P <0.05). Study group 1 appeared during the anti-tuberculosis treatment The number of drug-related adverse reactions was significantly less than that of the control group, with significant difference (P <0.05). The changes of peripheral blood T lymphocyte subsets in the two groups before and after treatment were significantly better than those in study group 1 and control group (P <0.05). CONCLUSION: The clinical effect of applying Chinese medicine TB pills and immunomodulators in combination with adjuvant treatment of patients with pulmonary tuberculosis during retreatment is very obvious.