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目的探讨急性白血病患者血浆纤维蛋白原水平的变化及其临床意义。方法采用Sysmex CA-1500全自动血凝仪对急性白血病患者治疗前后以及健康人血浆纤维蛋白原水平进行检测并比较差异。结果急性白血病初治患者纤维蛋白原水平明显增高,与对照组比较,差异有统计学意义(P<0.01),经治疗后达缓解者纤维蛋白原水平明显下降,与治疗前比较差异有统计学意义(P<0.01),而治疗后未缓解者与治疗前比较差异无统计学意义(P>0.05)。结论血浆纤维蛋白原在急性白血病的诊断及疗效判断中有一定的临床意义。
Objective To investigate the changes of plasma fibrinogen in patients with acute leukemia and its clinical significance. Methods The levels of plasma fibrinogen in patients with acute leukemia before and after treatment and healthy people were detected and compared by Sysmex CA-1500 automatic coagulation analyzer. Results The level of fibrinogen in patients with newly diagnosed acute leukemia was significantly higher than that in the control group (P <0.01). The level of fibrinogen after treatment was significantly lower than that before treatment (P <0.01). However, there was no significant difference between before treatment and after treatment (P> 0.05). Conclusion Plasma fibrinogen has some clinical significance in the diagnosis and treatment of acute leukemia.