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目的 观察高碘对已形成甲状腺肿大鼠的影响。 方法 复制Wistar大鼠甲状腺肿模型 ,分 2组 ,实验组及实验对照组 ,实验组又分 5组 ,常规饲料中投放不同浓度的碘 ,饲养 7个月后处死 ,将甲状腺组织常规方法固定并包埋 ,切片 ,HE染色 ,核仁组织区嗜银蛋白 (AgNOR)染色 ,用图象分析系统测量甲状腺滤泡上皮高度与甲状腺滤泡腔面积。 结果 实验组出现了胶质性甲状腺肿 ,不典型增生出现的百分率增加 ,甲状腺细胞的高度随饲料含碘量的增加而逐渐降低 ;其滤泡腔面积逐渐增大 ,实验组不典型增生区域的AgNOR颗粒数目增多。 结论 高碘可使药物性甲状腺胀变成高碘性甲状腺肿 ,并使某些区域增殖活跃 ,有恶变的可能。
Objective To observe the effect of high iodine on the formation of goiter in rats. Methods The model of goiter in Wistar rats was divided into two groups: experimental group and experimental control group. The experimental group was divided into five groups. Different concentrations of iodine were administered to normal rats. The rats were sacrificed 7 months later, and the thyroid tissue was fixed Embedded, sectioned, stained with hematoxylin and eosin, and stained with AgNOR. The height of thyroid follicular epithelium and thyroid follicular cavity area were measured by image analysis system. Results In the experimental group, the rate of atypical hyperplasia increased and the height of thyroid cells gradually decreased with the increase of iodine content in the experimental group. The area of the follicular cavity increased gradually. The area of atypical hyperplasia in the experimental group AgNOR particles increased in number. Conclusion High iodine can make the drug-induced thyroid gland swell into hyperiodic goiter, and make some areas proliferate actively, with the possibility of malignant transformation.