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血清抗-HBe和HBV-DNA同时阳性的慢性乙型肝炎患者常被认为体内感染有HBV pre C/C基因突变株,其γ-IFN疗效尚无一致意见。我们应用γ-IFN(安福隆)治疗此类病人30例,现将结果报告如下。 资料和方法 1 病例选择 60例慢性乙型肝炎均为我科住院及门诊患者,其中男31例,女29例;年龄8～54岁,平均34.5岁。60例随机分成A、B两组各30例两组性别、年龄、病史和ALT均具可比性(P>0.05)。全部病例均符合1995年5月北京第5次全国传染病寄生虫病会议修订的病毒性肝炎分型诊断标准,A组2例行肝活检病理诊断。
Serum anti-HBe and HBV-DNA in patients with positive chronic hepatitis B are often considered in vivo infection with HBV pre C / C gene mutations, the effect of γ-IFN is not yet agreed. We use γ-IFN (An Fulong) treatment of such patients in 30 cases, the results are reported below. Materials and Methods 1 Case Selection 60 cases of chronic hepatitis B were hospitalized and outpatient patients in our department, including 31 males and 29 females; aged 8 to 54 years, mean 34.5 years old. 60 cases were randomly divided into A and B groups of 30 cases of two groups of gender, age, history and ALT were comparable (P> 0.05). All the cases were in accordance with the diagnostic criteria of viral hepatitis classification revised by the 5th National Infectious Diseases Parasitology Conference in Beijing in May 1995, and 2 cases in group A were pathologically diagnosed with liver biopsy.