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主动脉瓣狭窄会导致经主动脉瓣的血流动力学发生变化 ,引起心脏形态、功能的改变 ,甚至导致心力衰竭、心律失常、猝死等严重后果。而瓣膜钙化是引起主动脉瓣狭窄的主要病因之一 ,常见于老年人。瓣膜置换术是目前唯一有效的根治手段 ,但费用高、风险大。研究发现 :影响钙化性主动脉瓣狭窄的危险因素、病理学改变、血液动力学变化、病因学机制和治疗手段等 ,都与冠状动脉粥样硬化性心脏病有许多相似之处 ,但也存在一定差异。两种疾病关系复杂 ,对于钙化性主动脉瓣狭窄与动脉粥样硬化的病因学机制的相关性也一直存在争议。对于严重无症状的主动脉瓣狭窄 ,主张在有血液动力学变化、心律失常、左室肥厚等存在时 ,尽早手术 ;对行冠状动脉搭桥术者 ,如发现存在着无症状的轻度瓣膜狭窄时 ,也建议同时进行瓣膜置换术。经皮导管主动脉瓣假体植入术、他汀类药物、转换酶抑制剂的应用 ,提供了更有效安全、简单经济的治疗手段和改善患者生活质量的可能
Aortic stenosis can result in changes in the hemodynamics of the aortic valve, causing changes in cardiac morphology and function, and even leading to serious consequences such as heart failure, arrhythmia, and sudden death. Valvular calcification is one of the main causes of aortic stenosis, common in the elderly. Valve replacement is the only effective radical cure, but the cost is high and the risk is high. The study found that risk factors for calcific aortic stenosis, pathological changes, hemodynamic changes, etiological mechanisms, and therapeutic approaches all have many similarities with coronary atherosclerotic heart disease, but they also exist Some difference. The complex relationship between the two diseases has also been controversial regarding the etiology of calcific aortic stenosis and atherosclerosis. For severe asymptomatic aortic stenosis, advocated in the presence of hemodynamic changes, arrhythmia, left ventricular hypertrophy, etc., as soon as possible surgery; line of coronary artery bypass surgery who found the existence of asymptomatic mild valvular stenosis It is also recommended that valve replacement be performed at the same time. Percutaneous catheter aortic valve prosthesis implantation, the use of statins and switch enzyme inhibitors, to provide more effective, safe, simple and economical treatment and to improve the quality of life of patients may