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本文对大鼠肝癌形成早期脂质过氧化物（ＬＰＯ）含量、谷胱甘肽硫转移酶（ＧＳＴ）活力、谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）活力和过氧化氢酶（ＣＡＴ）活力的变化规律进行了系统观察。结果表明：ＬＰＯ含量从ＤＥＮ（二乙基亚硝胺）注射后第二周开始逐渐上升，到第五周肝癌结节形成时达最高水平。ＧＳＴ活力在第一周上升，且可为含ＡＡＦ（０．０２％Ｎ－２－乙酰氨基笏）饲料的喂养而增强。ＧＳＨ－ＰＸ和ＣＡＴ活力均在第三周后逐渐下降。上述变化的有序性、规律性及其相互关系表明，脂质过氧化物增加及其清除酶系统机能障碍在肝癌早期病变形成中起重要作用。
In this paper, the formation of early lipid peroxidation (LPO), glutathione-S-transferase (GST) activity, glutathione peroxidase (GSH-PX) activity and catalase (CAT) in rat liver cancer ) The law of changes in vitality was systematically observed. The results showed that the content of LPO increased gradually from the second week after the injection of DEN (diethylnitrosamine) and reached the highest level during the fifth week of the formation of hepatocarcinoma nodules. GST activity increased during the first week and could be enhanced for feeding with AAF (0.02% N-2-acetylaminoanthraquinone) feed. Both GSH-PX and CAT activity gradually decreased after the third week. The above-mentioned changes in orderliness, regularity, and their correlations indicate that the increase in lipid peroxides and the dysfunction of the scavenging enzyme system play an important role in the early formation of liver cancer.