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目的:比较成人与儿童皮肌炎临床与实验室检查上的差异,指导临床实践。方法:回顾性总结和分析资料完整的皮肌炎患者的临床表现及实验室检查结果,采用精确概率法统计分析两组患者之间的差异。结果:在儿童组中女性发病明显高于男性,男:女为1:7;在临床表现上并发疾病及合并肿瘤的发生率成人组高于儿童组;儿童组表现发热、肌压痛、甲周红斑和/或毛细血管扩张(x2=11,75,P<0.05)的发生率高于成人组;实验室检查上LDH、CPK、AST在儿童的敏感性高于成人;成人组ESR值升高发生率高于儿童组,心肌受损和肺部感染发生率高于儿童组。结论:对儿童皮肌炎的皮损除检查眼睑外,应仔细检查甲周,对成人皮肌炎应注意排除存在恶性肿瘤的可能和注意心肌受损及肺部感染。
OBJECTIVE: To compare the clinical and laboratory findings of adult and pediatric dermatomyositis and to guide clinical practice. Methods: The clinical manifestations and laboratory findings of patients with complete dermatomyositis were retrospectively reviewed and analyzed. The exact difference was used to statistically analyze the differences between the two groups. Results: In the children group, the incidence of female was significantly higher than that of male, male: female was 1: 7. The clinical manifestations of concurrent diseases and the incidence of combined tumor were higher in adults than in children. Children in children showed fever, muscle tenderness, The incidence of erythema and / or telangiectasia (x2 = 11,75, P <0.05) was higher in adults than in adults; the sensitivity of laboratory tests to LDH, CPK and AST was higher in children than in adults; and the ESR in adults was increased The incidence was higher in children than in children. The incidence of myocardial damage and pulmonary infection was higher in children than in children. Conclusion: Children with dermatomyositis skin lesions in addition to checking the eyelids, should be carefully examined a week, adult dermatomyositis should be precluded the possibility of malignant tumors and pay attention to myocardial damage and pulmonary infection.