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基于对沙棘化学成份的调查,沙棘果中75%的乙醇提取物及其枝条中80%的丙酮氯仿可溶性物质可以抑制脂多糖(LPS)和重组小鼠的干扰素(IFN)—γ活性吞噬细胞即RAW264.7细胞中一氧化氮(NO)的生成。从果实提取物中可以分离出三种已知的黄酮、槲皮素(1)、kaempferol(2)、异鼠李素(3)和两种已知的萜类,果酸(4)和熊果酸(5)。该试验第一次从沙棘中提取出果酸,此外还从沙棘树皮的萃取物中分离出一种新的萜类、2—O—caffeoyl—谷酸(6),已知的萜类,鱼肝油醇酸(7),6—甲氧基—2H—1—苯芘(8)和β-醇(9)。并对RAW264.7细胞中的NO产物的活性抑制作用进行了研究。
Based on the chemical composition of seabuckthorn, 75% ethanol extract of Seabuckthorn and 80% acetone-chloroform soluble matter in its shoots can inhibit the activity of interferon (IFN) -γin lipopolysaccharide (LPS) and recombinant mouse phagocytes The formation of nitric oxide (NO) in RAW264.7 cells. Three known flavones, quercetin (1), kaempferol (2), isorhamnetin (3) and two known terpenoids, acid (4) and bears can be isolated from fruit extracts Acid (5). The test first extracted the acid from sea buckthorn, and in addition, a new terpenoid, 2-O-caffeoyl-glutamic acid (6), known terpenoids, (7), 6-methoxy-2H-1-phenylpyrene (8) and β-ol (9). The inhibitory effect of NO production in RAW264.7 cells was also studied.