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目的:通过大鼠在体小肠吸收实验方法,研究巴尼地平自微乳大鼠小肠吸收动力学。方法:以微乳肠循环液中的巴尼地平含量为指标,计算吸收速率常数(Ka)以及3 h的吸收百分数(PA)。结果:巴尼地平自微乳肠循环液灌流3 h后,胆管结扎的大鼠小肠药物吸收百分率为80.73%,胆管未结扎的大鼠小肠药物吸收百分率为81.74%。结论:巴尼地平自微乳化液透膜性好,吸收较快。胆管结扎与否小肠吸收率无显著影响(P>0.05)。
OBJECTIVE: To study the absorption kinetics of small intestine in rats treated with Baridipine. Methods: The absorption rate constant (Ka) and absorption percentage (PA) at 3 h were calculated using the content of barnidipine in the microemulsion enteric fluid as an index. Results: After 3 h of bilirubin perfusion, the intestinal absorption rate of bile duct ligation rats was 80.73%, and the intestinal absorption rate of bile duct non-ligated rats was 81.74%. Conclusion: Baridipine self-microemulsion has good permeability and fast absorption. No significant effect of bile duct ligation or intestinal absorption rate (P> 0.05).