论文部分内容阅读
目的:对胡椒科植物荜茇Piperlongum的化学成分进行研究。方法:荜茇用95%乙醇提取,依次用石油醚、氯仿、正丁醇萃取,对氯仿萃取部分采用各种柱色谱进行分离纯化,通过波谱数据分析(MS,1H-NMR,13C-NMR)进行结构鉴定。结果:从氯仿萃取部分分离鉴定了11个化合物,其中6个酰胺类生物碱,3个倍半萜,2个其他类化合物。分别鉴定为:类对香豆酰哌啶(coumaperine,1),N-5-(4-hydroxy-3-methoxyphenyl)-2E-pentenoyl piperidine(2),胡椒内酰胺A(piperolactam A,3),1-[1-oxo-5(3,4-methylenedioxyphenyl)-2E,4E-pentadienyl]-pirrolidine(4),1-[1-oxo-5(3,4-methylenedioxyphenyl)-2E-pentenyl]-pirroli-dine(5),1-[1-oxo-9(3,4-methylenedioxyphenyl)-2E,8E-nonadienyl]-pyrrolidine(6),姜黄酮[R-(-)-turmerone,7],octahydro-4-hydroy-3α-methyl-7-methylene-α-(1-methylethyl)-1H-indene-1-methanol(8),(+)-aphanamol I(9),二去甲氧基姜黄素(bisdeme-thoxycurcumin,10),去甲氧基姜黄素(demethoxycurcumin,11)。结论:化合物1~11均为首次从荜茇中分离得到。
Objective: To study the chemical composition of Piperlongum, a member of the family Piperaceae. Methods: The extract was extracted with 95% ethanol and extracted with petroleum ether, chloroform and n-butanol in turn. The chloroform fraction was separated and purified by various column chromatography and analyzed by spectroscopic data (MS, 1H-NMR, 13C-NMR). Structure identification. RESULTS: Eleven compounds were isolated and identified from chloroform extracts, of which 6 were amide alkaloids, 3 sesquiterpenes, and 2 other compounds. They were identified as: coumaperine (1), N-5-(4-hydroxy-3-methoxyphenyl)-2E-pentenoyl piperidine (2), piperolactam A (3), 1-[1-oxo-5(3,4-methylenedioxyphenyl)-2E,4E-pentadienyl]-pirrolidine(4),1-[1-oxo-5(3,4-methylenedioxyphenyl)-2E-pentenyl]-pirroli -dine(5),1-[1-oxo-9(3,4-methylenedioxyphenyl)-2E,8E-nonadienyl]-pyrrolidine(6), ginger flavonoids [R-(-)-turmerone,7], octahydro- 4-hydroy-3α-methyl-7-methylene-α-(1-methylethyl)-1H-indene-1-methanol(8), (+)-aphanamol I(9), didemethoxy curcumin (bisdeme -thoxycurcumin, 10), demethoxycurcumin (11). Conclusion: Compounds 1-11 were isolated from the cockroach for the first time.