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目的观察解毒活血中药(虎杖、山楂)配伍对ApoE基因敲除ApoE-/-小鼠巨噬细胞源性泡沫细胞内过氧化体增殖物激活受体γ(PPARγ)、三磷酸腺苷结合盒转运体A1(ABCA1)、CD36 mRNA表达的影响,从基因水平探讨解毒活血中药配伍对动脉粥样硬化泡沫细胞形成的干预机制。方法培养ApoE-/-小
Objective To observe the effects of detoxification and activating blood circulation Chinese medicine (Polygonum cuspidatum, hawthorn) on the expression of PPARγ, ATPF-A1 and AβE1 in macrophage-derived foam cells of ApoE knockout ApoE - / - ABCA1) and CD36 mRNA expression, and to explore the intervention mechanism of traditional Chinese medicine detoxification and activating blood compatibility on the formation of atherosclerotic foam cells at the gene level. Methods ApoE - / - mice were cultured