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肺癌是人类常见的恶性肿瘤,肺腺癌是其主要类型之一。细支气管肺泡癌(bronchioloalveolar lung carcinoma,BAC)是肺腺癌的一个特殊类型。肺泡上皮不典型腺瘤样增生(atypical adenomatous hyperplasia,AAH)可能是BAC或腺癌的癌前病变,甚至是其早期癌。表皮生长因子受体(epidermal growth factor receptor,EGFR)的过表达和(或)突变与肺癌尤其是非小细胞肺癌(non-small-cell lung cancer,NSCLC)的发生、发展、侵袭和转移等密切相关。
Lung cancer is a common human malignancy, lung adenocarcinoma is one of its main types. Bronchioloalveolar lung carcinoma (BAC) is a special type of lung adenocarcinoma. Alveolar epithelial atypical adenomatous hyperplasia (AAH) may be a precancerous lesion of BAC or adenocarcinoma, and even its early stage of cancer. Overexpression and / or mutation of epidermal growth factor receptor (EGFR) is closely related to the occurrence, development, invasion and metastasis of lung cancer, especially non-small-cell lung cancer (NSCLC) .