论文部分内容阅读
目的观察扶正祛痰方、顺铂及扶正祛痰方与顺铂联合治疗非小细胞肺癌的疗效,探索扶正祛痰方的抗癌机制及对顺铂的增效减毒作用。方法将40只小鼠分为对照组、扶正祛痰方组、顺铂组和联合组,每组各10只小鼠。对照组给予常规喂养,扶正祛痰方组每天中药灌胃,顺铂组腹腔注射顺铂,每周两次,联合组结合上述两种方法给药,所有小鼠21天后处死。小鼠处死前取血,采用ELISA法检测IL-2;小鼠处死后,测肿瘤体积及脾脏、胸腺重量。结果扶正祛痰方组、顺铂组和联合组中的抑瘤率分别为66.9%、68.8%和71.8%;扶正祛痰方组和联合组肺癌小鼠的脾脏指数和胸腺指数较顺铂组高,且差异具有统计学意义(P<0.05);扶正祛痰方组和联合组小鼠血清中IL-2也较顺铂组高,差异具有统计学意义(P<0.05)。结论扶正祛痰方具有一定的抑瘤作用,且扶正祛痰方联合顺铂同时使用,疗效更加确定,并能有效减少顺铂的毒副作用。
Objective To observe the curative effect of Fuzheng Qutan Recipe, Cisplatin and Fuzheng Qutan Recipe combined with Cisplatin in the treatment of non-small cell lung cancer and explore the anticancer mechanism of Fuzheng Qutan Fang and the synergistic and attenuated effect of Cisplatin. Methods Forty mice were divided into control group, Fuzheng Qutanfang group, cisplatin group and combination group, with 10 mice in each group. The control group was given routine feeding. Fuzheng Qutan Prescription Group was given gavage daily. Cisplatin group was intraperitoneally injected with cisplatin twice a week. All the mice were sacrificed after 21 days. The mice were sacrificed before sacrifice, and IL-2 was measured by ELISA. After the mice were sacrificed, the tumor volume and the weight of the spleen and thymus were measured. Results The inhibition rates of Fuzheng Qutan Fang group, cisplatin group and combination group were 66.9%, 68.8% and 71.8%, respectively. The spleen index and thymus index of Fuzheng Qutanfang group and combination group were significantly higher than that of cisplatin group The difference was statistically significant (P <0.05). The serum levels of IL-2 in Fuzheng Qutanfang group and the combined group were also higher than those in cisplatin group (P <0.05). Conclusions Fuzheng Qutan Recipe has anti-tumor effect, and Fuzheng Qutan Recipe combined with Cisplatin is used simultaneously, the curative effect is more determined, and the side effects of cisplatin can be effectively reduced.