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目的探讨成人外周血胆红素水平与高血压的关系。方法对江苏省苏南地区整群抽样的某乡镇社区2238人进行现场流行病学调查,分为高血压组和对照组进行病例对照研究。高血压组和对照组组间计量资料比较采用t检验,组间分类资料比较采用χ2检验,关联分析应用Logistic回归分析。结果高血压组的年龄、体质量指数(BMI)、血糖(Glu)、总胆固醇(TCH)和低密度脂蛋白胆固醇(LDL-C)均显著高于对照组(P<0.05),2组间的总胆红素(TBIL)、直接胆红素(DBIL)和间接胆红素(IDBIL)差异均无统计学意义(P>0.05);进一步按年龄进行分层分析,结果发现在<55岁的年龄组中,DBIL与高血压患病风险升高存在显著关联(P<0.05),而在≥55岁人群中,TBIL和IDBIL均与高血压患病风险降低有关(P<0.05);进一步调整年龄、性别、BMI、TCH、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、LDL-C、Glu、吸烟与饮酒混杂因素后,在<55岁年龄组,DBIL与高血压患病风险升高仍存在关联(P<0.05);总人群的舒张压(DBP)和DBIL呈正相关(P<0.05)。结论 <55岁的人群中胆红素水平升高与高血压患病风险增加存在关联,而在≥55岁年龄组胆红素水平升高可能具有一定保护作用,结果仍需进一步研究加以证实。
Objective To explore the relationship between the level of bilirubin in adult peripheral blood and hypertension. Methods A total of 2238 people in a cluster of towns in Jiangsu province were enrolled in this study, and were divided into hypertension group and control group for case-control study. The t test was used to compare the metrological data between hypertension group and control group. Chi-square test was used to compare the classification data between groups. Logistic regression analysis was used to analyze the association. Results The age, body mass index (BMI), blood glucose (Glu), total cholesterol (TCH) and low density lipoprotein cholesterol (LDL-C) in hypertensive group were significantly higher than those in the control group (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IDBIL) showed no significant difference (P> 0.05). According to the stratification analysis by age, (P <0.05). However, both TBIL and IDBIL were associated with the decreased risk of hypertension (P <0.05) in people aged ≥ 55 years, and further After adjusting for age, sex, BMI, TCH, triglyceride (TG), HDL-C, LDL-C, Glu, smoking and drinking mixed factors, The prevalence of hypertension was still associated with increased risk (P <0.05). DBP was positively correlated with DBIL in the general population (P <0.05). Conclusions The elevated bilirubin level in 55-year-old population is correlated with the increased risk of hypertension. However, elevated bilirubin level may have a protective effect in ≥55-year-old group. The results still need further study to confirm.