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抗氧化蛋白Peroxiredoxins是有机体内抗过氧化的重要成员,该类蛋白包含保守的半胱氨酸残基,通过与硫氧化蛋白的协同作用消除组织及细胞内的有害过氧化物。目前多种消化道肿瘤如肝癌、胃癌、胰腺癌等组织中均发现有高表达的抗氧化蛋白,推测其可能是肿瘤的潜在标志物,且已有实验证实,抑制抗氧化蛋白表达可增加消化道肿瘤对放射、化学治疗的敏感性。
Antioxidant proteins Peroxiredoxins are important members of the body against peroxidation, these proteins contain a conserved cysteine residues, through the synergistic effect with sulfur oxidation protein to eliminate tissue and intracellular harmful peroxides. Currently a variety of gastrointestinal tumors such as liver cancer, gastric cancer, pancreatic cancer and other tissues were found in high expression of antioxidant protein, suggesting that it may be a potential tumor markers, and experiments have shown that inhibition of antioxidant protein expression can increase digestion Road tumor radiation, chemotherapy sensitivity.