Dear Editor,rnHuman papillomaviruses (HPV) are a large group (＞ 200 genotypes) of small double-stranded DNA viruses (https://pave.niaid.nih.gov/).Although infections by most HPV types are asymptomatic,persistent infections in cervical and ano-genital epithelia by high-risk HPV can lead to the development of cervical and ano-genital intraepithelial neoplasia and invasive carcinoma.Of 15 known high-risk HPV types,HPV 16 and HPV 18 are the two most common types inducing the development of cervical,anal,and a small portion of oropharyngeal cancers and are found in ～70％ of cervical cancer cases worldwide (Munoz et al.,2003).