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目的:研究胆舒胶囊的抗炎镇痛作用。方法:通过二甲苯致小鼠耳廓肿胀实验、角叉菜胶致大鼠足肿胀实验和小鼠醋酸扭体实验观察胆舒胶囊的抗炎镇痛作用。结果:低剂量胆舒胶囊可明显降低二甲苯致小鼠耳片肿胀度;高、中剂量胆舒胶囊可明显降低角叉菜胶致大鼠足肿胀度;胆舒胶囊中、低剂量可明显降低醋酸致小鼠扭体反应次数。结论:胆舒胶囊具有明显的抗炎镇痛作用,其镇痛作用表现出随剂量减少效果越好,而消炎作用表现出相反结果。
Objective: To study the anti-inflammatory and analgesic effect of biliary capsule. Methods: The anti-inflammatory and analgesic effect of bishu capsule was observed by xylene-induced mouse ear swelling test, carrageenan-induced rat foot swelling test and mouse acetic acid writhing test. Results: Low dose of bishu capsule can significantly reduce xylene-induced ear swelling in mice; high and medium dose of bishu capsule can significantly reduce carrageenan-induced foot swelling in rats; biliary capsule low dose can be significantly Reduce the number of writhing reactions caused by acetic acid in mice. Conclusion: Ganshu capsule has obvious anti-inflammatory and analgesic effects. The analgesic effect shows the better effect with dose reduction, while the anti-inflammatory effect shows the opposite result.