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丙酸乙酯(EP)和乙酸异丙酯(IA)与当前应用的甲醛叔丁醚(MTBE)相比,被认为是更具良好物理化学性能的溶胆石剂。此研究目的是比较三者的溶石能力和细胞毒性。 方法:从33例多发性胆石症患者取出的胆石中采用形态相似的胆石,每位选出4枚胆石成1组,分别用3种溶剂溶解来比较溶解能力;大鼠空肠段置于各种溶剂或盐水中,然后灌注各种主动吸收和被动透过的标记物来评估细胞毒性。 结果:33组结石在EP中29枚(88％)完全溶解,未有残留。而在IA和MTBE则有25枚(76％)和26枚(79％)结石完全溶解,但这种差异没有统计学显著性(P=0.43),13组结石在3
Ethyl propionate (EP) and isopropyl acetate (IA) are considered to be more well-defined physicochemical properties of the cholestyrite agent than the currently used formalin (MTBE). The purpose of this study was to compare the ability of the three to dissolve rock and cytotoxicity. Methods: Cholelithiasis from 33 cases of patients with multiple cholelithiasis was collected, and four gallstones were selected into one group. Each group was dissolved in three solvents to compare the dissolubility. The jejunum of rats were placed in various kinds Solvent or saline, and then perfusion of various actively absorbed and passively-permeabilized markers to assess cytotoxicity. Results: Twenty-three (88%) of the 33 groups of stones were completely dissolved in the EP without any residue. However, 25 (76%) and 26 (79%) stones were completely dissolved in both IA and MTBE, but this difference was not statistically significant (P = .43)