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目的通过检测正常人群和狼疮肾炎患者的尿微量白蛋白(m-Alb),探讨其对早期狼疮肾炎的诊断价值。方法采用免疫透射比浊法检测45例狼疮肾炎患者的尿微量白蛋白,并与20例健康人员作对照。结果 20例正常对照组中尿微量白蛋白阳性0例,45例狼疮肾炎组阳性19例,两组比较差异有统计学意义(P<0.01),且狼疮肾炎患者随着病程的延长,尿微量白蛋白阳性率不断升高。结论尿微量白蛋白是诊断狼疮肾炎早期损伤的可靠生化指标,对临床的早诊断、早治疗有着重要的参考价值。
Objective To evaluate the diagnostic value of m-Alb in normal people and lupus nephritis patients with early lupus nephritis. Methods Urine microalbuminuria was detected in 45 patients with lupus nephritis by immunoturbidimetry and compared with 20 healthy people. Results There were 0 urinary albumin in 20 normal controls and 19 in 45 patients with lupus nephritis. The difference between the two groups was statistically significant (P <0.01), and the patients with lupus nephritis had longer duration of disease and urine micro-amount Albumin positive rate rising. Conclusion Urinary microalbumin is a reliable biochemical indicator for the early diagnosis of lupus nephritis, which has an important reference value for clinical diagnosis and early treatment.