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目的探讨左甲状腺素钠联合甲状腺片治疗甲状腺功能减退的临床疗效。方法选取2014年4月—2015年1月许昌县人民医院收治的甲状腺功能减退患者84例,根据用药不同分为观察组与对照组,各42例。观察组患者予以左甲状腺素钠联合甲状腺片治疗,对照组患者予以甲状腺片治疗。观察两组患者临床疗效、不良反应发生情况及治疗前后游离三碘甲状腺原氨酸(FT_3)、游离四碘甲状腺原氨酸(FT_4)、促甲状腺激素(TSH)、三酰甘油(TG)、总胆固醇(CHOL)水平。结果观察组患者总有效率高于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05);治疗前两组患者FT_3、FT_4、TSH、TG、CHOL水平比较,差异无统计学意义(P>0.05),治疗后观察组患者FT_3、FT_4水平高于对照组,TSH、TG、CHOL水平低于对照组,差异有统计学意义(P<0.05)。结论左甲状腺素钠联合甲状腺片治疗甲状腺功能减退的临床疗效显著,可改善患者甲状腺功能,且不良反应少。
Objective To investigate the clinical efficacy of levothyroxine combined with thyroid tablets in the treatment of hypothyroidism. Methods Eighty-four patients with hypothyroidism who were treated in Xuchang County People’s Hospital from April 2014 to January 2015 were selected and divided into observation group and control group according to different drugs. Patients in the observation group were treated with levothyroxine combined with thyroid tablets, and patients in the control group were treated with thyroid tablets. The clinical efficacy, adverse reactions and free triiodothyronine (FT_3), free tetraiodothyronine (FT_4), thyrotropin (TSH), triglyceride (TG) Total cholesterol (CHOL) levels. Results The total effective rate in the observation group was higher than that in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05) FT_4, TSH, TG and CHOL levels were not significantly different (P> 0.05). After treatment, the levels of FT_3 and FT_4 in the observation group were higher than those in the control group, while the levels of TSH, TG and CHOL in the observation group were lower than those in the control group Significance (P <0.05). Conclusion The clinical efficacy of levothyroxine combined with thyroid tablets in treatment of hypothyroidism is significant, which can improve the thyroid function in patients with less adverse reactions.