目的:分析研究预防性宫体注射卡前列素氨丁三醇在预防和治疗产后出血高危因素孕妇剖宫产术中的临床效果,为临床用药提供一定参考。方法:于2010年3月到2014年3月对在我院进行治疗的存在产后出血高危因素的剖宫产指征的102例产妇进行对照研究,按照入院先后随机分为观察组和对照组,观察组患者术后常规宫体注射缩宫素联合卡前列素氨丁三醇,对照组患者术后常规宫体注射缩宫素、米索前列醇、葡萄糖酸钙以及垂体后叶素等联合预防治疗,对两组患者术中、术后出血量,预防和治疗效果进行比较分析。结果:观察组患者术后、术后2h以及术后24h出血量显著低于对照组(P<0.05);观察组患者产后出血发生率和输血率均显著低于对照组(P<0.05);观察组患者止血时间显著短于对照组(P<0.05);两组患者不良反应发生率之间无显著差异(P>0.05)。结论:对存在产后出血高危因素的剖宫产指征的产妇应用常规宫体注射缩宫素联合卡前列素氨丁三醇,较之传统缩宫素,可有效减少术中和术后2h、24h出血量,降低产后出血发生率和输血率,缩短止血所需时间,不失为预防、治疗产后出血的行之有效的实施方案,可在临床加以推广普及。 Objective: To analyze the clinical effect of preventive intrauterine injection of carboprost trometamol in the prevention and treatment of cesarean section in pregnant women at risk of postpartum hemorrhage, and to provide some reference for clinical use. Methods: From March 2010 to March 2014, 102 pregnant women with cesarean indications who were at risk of postpartum hemorrhage who were treated in our hospital were compared. Randomly divided into observation group and control group according to admission, The patients in the observation group were given conventional oxytocin combined with carboprost trometamol and the control group received conventional oxytocin, misoprostol, calcium gluconate and vasopressin after the operation Treatment, the two groups of patients during surgery, postoperative blood loss, prevention and treatment of comparative analysis. Results: The bleeding volume in postoperative, postoperative 2h and postoperative 24h in observation group was significantly lower than that in control group (P <0.05). The incidence of postpartum hemorrhage and transfusion rate in observation group were significantly lower than those in control group (P <0.05). The bleeding time in the observation group was significantly shorter than that in the control group (P <0.05). There was no significant difference between the two groups in the incidence of adverse reactions (P> 0.05). Conclusion: The women with cesarean indications at risk of postpartum hemorrhage using conventional uterine injection of oxytocin combined with carboplatin trometamol, compared with the traditional oxytocin, can effectively reduce intraoperative and postoperative 2h, 24h bleeding, reduce the incidence of postpartum hemorrhage and transfusion rate, shorten the time required to stop bleeding, after all, prevention and treatment of postpartum hemorrhage effective implementation of the program can be popularized in clinical practice.