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目的:将富血小板纤维蛋白(Platelet-rich fibrin,PRF)与自体髂骨松质骨块混合进行骨移植手术,观察PRF能否促进骨形成,减少植骨术后的骨吸收。方法:犬8只,制备犬上颌骨双侧牙槽突裂模型,左、右侧裂隙随机分入实验组(骨块+PRF)及对照组(骨块),于术后当日、2个月、4个月行CT检查,测量植骨区骨量变化,术后4个月处死动物,植骨区取材,行组织学检查及显微CT检查。结果:术后2个月、4个月时实验组的骨量减少程度小于对照组(P<0.01);实验组在骨体积分数、骨小梁分离度方面大于对照组(P<0.01),在骨小梁厚度方面未见明显差异(P>0.05)。结论:富血小板纤维蛋白(PRF)对于碎骨块形式的植骨手术,可以促进新骨生成,减少植骨手术后的骨吸收。
OBJECTIVE: To investigate whether PRF can promote bone formation and reduce bone resorption after bone graft surgery by mixing platelet-rich fibrin (PRF) and autologous iliac cancellous bone for bone transplantation. Methods: Eight dogs were used to prepare bilateral maxillary alveolar cleft fracture model. The left and right fissures were randomly divided into experimental group (PRF + PRF group) and control group (BLA). On the day after surgery, 2 months , 4-month CT scan to measure the amount of bone graft bone mass changes, 4 months after the animals were sacrificed, bone graft area, histological examination and microscopic CT examination. Results: The osteopenia of the experimental group was less than that of the control group (P <0.01) at 2 months and 4 months after operation. The experimental group was larger than the control group in terms of bone volume fraction and trabecular separation (P <0.01) No significant difference in trabecular thickness (P> 0.05). CONCLUSIONS: Platelet-rich fibrin (PRF) can promote new bone formation and reduce bone resorption after bone graft surgery.