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目的:探讨银锌霜对恶性肿瘤患者静脉化疗药物所致的渗漏性损伤的临床疗效。方法:选择恶性肿瘤住院病例中发生化疗药物渗漏性损伤患者38例,随机分为治疗组和对照组各19例。治疗组用银锌霜外涂于创面,治疗化疗药物渗漏所致的皮肤溃烂、坏死,并于常规外科换药治疗对照,观察两组疗效、愈合时间及疼痛持续时间。结果:治疗组疗效明显优于对照组,平均愈合时间明显少于对照组,治疗组疼痛持续时间明显缩短,P<0.05。结论:银锌霜治疗化疗药物渗漏性损伤疗效好、起效快,又能缩短患者疼痛持续时间,可广泛地应用于临床。
Objective: To investigate the clinical efficacy of silver-zinc cream on the leakage injury caused by intravenous chemotherapy in patients with malignant tumors. Methods: Thirty-eight patients with chemotherapy-induced leakage in hospitalized patients were randomly divided into treatment group (n = 19) and control group (n = 19). The treatment group was treated with silver-zinc cream on the wound surface to treat skin ulceration and necrosis caused by leakage of chemotherapy drugs. The control group was treated with routine dressing change, and the curative effect, healing time and duration of pain were observed. Results: The curative effect of the treatment group was obviously better than that of the control group, the average healing time was obviously less than that of the control group, and the pain duration of the treatment group was significantly shorter (P <0.05). CONCLUSION: Silver-Zinc cream is effective in treating chemotherapy-induced leakage injury, has rapid onset of action, and shortens the duration of pain in patients. It can be widely used in clinical practice.