POEMS综合征是一种原因及发病机制尚未完全明了的累及神经、内分泌、血液、消化、皮肤、浆膜腔等多系统损害的综合征。1938年澳大利亚学者Scheinker首次报道了1例胸骨孤立性骨硬化性骨髓瘤伴多发性神经病、前胸部皮肤增厚和色素沉着。1987年国内陆续有报道本病,但仍属临床少见病 POEMS syndrome is one of the causes and pathogenesis has not yet fully understood, involving neurological, endocrine, blood, digestive, skin, serosa and other multi-system damage syndrome. In 1938, Scheinker, an Australian scholar, reported for the first time one case of solitary sternal myeloma with multiple neuropathies, thickening of the thorax and hyperpigmentation. In 1987, the disease was reported in China one after another, but it is still a rare clinical disease