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目的探讨HIV感染者和艾滋病患者(HIV/AIDS)长期免费抗病毒治疗的效果和换药原因。方法首都医科大学附属北京佑安医院2005年1月1日至2010年12月31日收治的543例免费抗HIV治疗的患者纳入本研究,采集治疗前和治疗后每隔6个月的临床和实验室检查数据并进行分析。结果 543例患者随访中位时间为36个月。总体依从率为98.0%,治疗90个月后患者的病毒载量在检测不到水平者占94.0%,CD4~+T细胞计数由基线时161个/mm~3增长到治疗90个月时437个/mm~3(P<0.001)。换药主要原因包括骨髓抑制、耐药、皮疹、消化道症状和神经系统症状。结论抗HIV治疗具有持久的良好效果,在选择药物时应根据药物的特点进行个体化治疗,密切观察病情变化,妥善处理换药的有关问题。
Objective To explore the effect of long-term free anti-virus therapy and the cause of drug replacement for HIV-infected persons and AIDS patients (HIV / AIDS). Methods 543 cases of patients with anti-HIV treatment who were admitted to Beijing You’an Hospital, Capital Medical University from January 1, 2005 to December 31, 2010 were enrolled in this study. The clinical and clinical data were collected before and 6 months after treatment Laboratory test data and analysis. Results The median follow-up of 543 patients was 36 months. The overall compliance rate was 98.0%. After 90 months of treatment, the patients’ viral load was undetectable at 94.0%. The CD4 ~ + T cell count increased from 161 / mm ~ 3 at baseline to 90 months after treatment. 437 A / mm ~ 3 (P <0.001). The main reasons for dressing change include myelosuppression, drug resistance, rash, gastrointestinal symptoms and neurological symptoms. Conclusion The anti-HIV treatment has a long-lasting good effect. When selecting drugs, individualized treatment should be based on the characteristics of the drugs, closely observe the changes of the disease, and properly handle the problems related to dressing change.