Effects of PAHs on Biotransformation Enzymatic Activities in Fish

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Biotransformation and detoxification responses to the exposure to five polycyclic aromatic hydrocarbons were investigated in crucian(Carassius auratus). Juvenile crucian were treated with a single intraperitoneal injection of each compound at dosages of 0.1, 1.0, 2.0, 5.0 and 8.0(or 10.0) mg/kg and sacrifced 15 d later to determine 7-ethoxyresorufin-O-deethylase(EROD) and glutathione S-transferases(GST) activities in gill S9 fractions. EROD activity is significantly increased by benzo(b)fluoranthene and indeno(1,2,3-cd)pyrene at all the doses. High dosages of PAHs induced GST activity and the inducing ability of them increased in the following order: fluorene< fluoranthene
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