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目的:探讨血清胱抑素C(Cys C)水平与2型糖尿病伴冠心病的关系。方法:收集40例单纯2型糖尿病患者(DM组)、120例2型糖尿病伴冠心病(CHD)患者(DM+CHD组)及40例健康者(对照组)的血清。分别测定基础代谢率、血压、血脂、血清糖化血红蛋白及Cys C水平。结果:血清Cys C水平在DM组[(1.58±0.78)mg/L]、DM+CHD组[(2.12±0.94)mg/L]较对照组[(0.82±0.23)mg/L]明显升高,差异有统计学意义(P<0.01),DM+CHD组明显高于DM组(P<0.05)。冠状动脉狭窄支数越多,血清Cys C水平越高。结论:2型糖尿病伴CHD患者的血清Cys C水平增高,且随冠状动脉狭窄病变支数的相应增加呈增高趋势,提示Cys C在2型糖尿病伴CHD的发生发展中起一定作用。
Objective: To investigate the relationship between serum cystatin C (Cys C) and type 2 diabetes with coronary heart disease. Methods: Serum was collected from 40 patients with type 2 diabetes mellitus (DM group), 120 type 2 diabetes mellitus patients with coronary heart disease (CHD) and 40 healthy controls (control group). The basal metabolic rate, blood pressure, blood lipids, serum HbA1c and Cys C levels were measured. Results: Serum Cys C level was significantly higher in DM group [(1.58 ± 0.78) mg / L] and DM + CHD group (2.12 ± 0.94 mg / L vs [0.82 ± 0.23 mg / L] , The difference was statistically significant (P <0.01), DM + CHD group was significantly higher than the DM group (P <0.05). The more coronary stenosis count, the higher the serum Cys C level. Conclusions: Serum Cys C levels are elevated in patients with type 2 diabetes mellitus complicated with coronary heart disease and increased with the corresponding increase of coronary artery stenosis, suggesting that Cys C may play a role in the development of type 2 diabetes with CHD.