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动脉粥样硬化(As)不稳定斑块也称易损斑块.不稳定斑块表面溃疡形成、破裂及继发血栓形成,是引起急性心脑血管事件的主要病理基础。药物治疗对防治不稳定斑块破裂的发生,降低急性心脑血管事件的发病率具有重要意义。治疗不稳定斑块的药物主要有他汀、抗氧化剂等,其主要药理学机制是抗炎、抗氧化、调节细胞因子、抑制MMPs活性等作用。本文对不稳定斑块有治疗作用的药物研究与应用进展做一综述,为急性心脑血管事件的治疗提供理论依据及线索。
Atherosclerosis (As) also known as vulnerable plaque vulnerable plaque surface ulcer formation, rupture and secondary thrombosis, is the main pathological cause of acute cardiovascular and cerebrovascular events. Medical treatment of unstable plaque rupture prevention and reduce the incidence of acute cardiovascular and cerebrovascular events of great significance. The treatment of unstable plaque drugs mainly statins, antioxidants, the main pharmacological mechanisms are anti-inflammatory, anti-oxidation, regulation of cytokines, inhibition of MMPs activity and so on. This review summarizes the research and application progress of drugs that have a therapeutic effect on unstable plaque, and provides theoretical basis and clues for the treatment of acute cardiovascular and cerebrovascular events.