α1型肾上腺素能受体(α1-adrenoceptor,α1-AR)是α肾上腺素能受体的亚型之一。该受体广泛分布于机体的各种器官、组织和细胞,并介导了机体内源性儿茶酚胺的大多数反应,参与了机体的许多基本生理过程,诸如交感神经传导、心脏变力变时作用、血管收缩、肝脏代谢以及泌尿生殖系统平滑肌活动的调控[1-2]。有关α1-AR病理生理研究已成为近来的热点,本文就这一专题的研究综述如下。 α1-adrenoceptor (α1-AR) is one of the subtype of α adrenergic receptors. The receptor is widely distributed in various organs, tissues and cells of the body and mediates most of the body’s intrinsic catecholaminergic responses and is involved in many of the body’s basic physiological processes such as sympathetic conduction and cardiac variability , Vasoconstriction, liver metabolism and urogenital smooth muscle activity regulation [1-2]. The research on the pathophysiology of α1-AR has become a hot issue in recent years. The research on this topic in this paper is summarized as follows.