用电位滴定法及分光光度法研究了顺二氨二水合铂(Ⅱ)离子与半胱氨酸、蛋氨酸及谷胱甘肽的络合反应.用电位滴定法测定[(NH_3)_2PtA](A 为氨基酸)型混合配体络合物的形成常数β,测得 A 为半胱氨酸及蛋氨酸时,1gβ分别为7.55及8.70.按(?)=0.5处 pA 计算谷胱甘肽络合物的最可能1gβ为9.00.用 Job 分光光度法测得结果与之符合.据此讨论了络合物的可能结构.在所有情况中,硫可能是优先配位原子. The complexation of cisplatin (Ⅱ) with cysteine, methionine and glutathione was studied by potentiometric titration and spectrophotometry. [(NH_3) _2PtA] (A is an amino acid) type ligand complex formation constant β, measured when A is cysteine ​​and methionine, 1gβ were 7.55 and 8.70. (?) = 0.5 pA calculated glutathione The most probable 1gβ for the compound is 9.00. The result is in agreement with the one measured by the Job spectrophotometry. The possible structure of the complex is thus discussed. In all cases sulfur may be a preferentially coordinating atom.