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系统性红斑狼疮(SLE)是一种典型的系统性自身免疫性疾病,以多器官受累和多系统损害为特点,临床表现、病程发展及病情转归均具有较大的个体差异。与一般人群相比,SLE患者合并恶性肿瘤的发生率及进展速度显著增加,常见恶性肿瘤类型有非霍奇金淋巴瘤(NHL)、子宫颈癌以及支气管肺癌等。遗传易感性、慢性抗原刺激、过度自身免疫反应及免疫抑制剂的长期使用,可能是SLE患者恶性肿瘤发生率升高的原因。本文对SLE患者常见各种合并恶性肿瘤的分子病理学、流行病学及临床方面的研究进展进行综述。
Systemic lupus erythematosus (SLE) is a typical systemic autoimmune disease characterized by multiple organ involvement and multiple system damage. Clinical manifestations, course of disease progression, and prognosis of illness have large individual differences. Compared with the general population, the incidence of SLE patients with malignant tumors and the rate of progress was significantly increased, common types of malignant tumors are non-Hodgkin’s lymphoma (NHL), cervical cancer and bronchial lung cancer. Genetic predisposition, chronic antigen stimulation, excessive autoimmune reactions and the long-term use of immunosuppressive agents may be the reason for the increased incidence of malignant tumors in SLE patients. This article reviews the molecular pathology, epidemiology and clinical research of various common malignant tumors in patients with SLE.