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在恶性肿瘤与免疫反应之间的关系,仅以肿瘤的免疫监视学说来解释,看来是过分简单化了。肿瘤的发生究竟是识别机制的丧失或是免疫反应的低下还不清楚。本文将复习讨论免疫反应与头颈部癌瘤特别是口腔鳞癌之间的关系。免疫反应对癌瘤影响的证据一、癌肿发生率随年龄而增高癌瘤虽然可以发生在任何年龄,但大多数肿瘤(包括口腔肿瘤)发生的危险性随年龄而增加,因为,随着年龄增大,机体的细胞免疫反应逐渐下降。这可从二硝基氯苯(DNCB)、结核菌素(OT)的皮试损害以及淋巴细胞对各种植物血凝素(Lectins)例如PHA的反应受损得到证明。
The relationship between malignancy and the immune response, explained by the tumor’s immune surveillance theory, seems to be overly simplistic. It is unclear whether the occurrence of tumors is the loss of recognition mechanism or the low immune response. This article will review the relationship between the immune response and head and neck cancers, especially oral squamous cell carcinoma. Evidence of the effects of immune response on cancerous tumors 1. Incidence of cancer increases with age Although cancerous tumors can occur at any age, the risk of developing most tumors (including oral tumors) increases with age because, with age, Increased, the body’s cellular immune response gradually decreased. This is evidenced by the skin lesions of dinitrochlorobenzene (DNCB), tuberculin (OT) and the impaired response of lymphocytes to various lectins such as PHA.