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背景:大量临床研究证实,脊髓损伤区域的微环境通过高压氧可获得显著改善,但高压氧对脑损伤微环境有何影响呢?目的:观察高压氧治疗对大鼠脑梗死区神经再生微环境及神经功能恢复的影响。方法:构建大脑中动脉阻断制作局灶性脑梗死模型大鼠,并进行高压氧治疗,设假手术组和模型组作对照,假手术组不结扎颈内动脉不干预,模型组造模后模拟除压力和氧浓度以外的其他高压氧治疗过程及环境条件。结果与结论:与模型组相比,治疗后第16天高压氧组的大鼠肢体功能评分、术后14 d脑梗死区组织生长相关蛋白43表达均升高(P<0.05),术后24h梗死灶体积均降低(P<0.05)。结果证实,高压氧治疗促进脑梗死模型大鼠神经再生微环境及神经功能的恢复。
BACKGROUND: A large number of clinical studies confirm that the microenvironment of spinal cord injury area can be significantly improved by hyperbaric oxygen, but what is the effect of hyperbaric oxygen on microenvironment of brain injury? OBJECTIVE: To observe the effects of hyperbaric oxygen therapy on nerve regeneration microenvironment And neurological recovery. Methods: The middle cerebral artery was established to block the focal cerebral infarction model rats and hyperbaric oxygen therapy was performed. The sham - operation group and the model group were given as control. The sham operation group did not intervene the internal carotid artery without intervention. In addition to pressure and oxygen concentration in addition to other hyperbaric oxygen treatment process and environmental conditions. RESULTS AND CONCLUSION: Compared with the model group, the limb function score of hyperbaric oxygen group on day 16 after treatment and the expression of tissue growth associated protein 43 in cerebral infarction area increased on the 14th day (P <0.05) Infarct size decreased (P <0.05). The results confirmed that hyperbaric oxygen therapy to promote cerebral infarction model of nerve regeneration microenvironment and recovery of neurological function.