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从鸦胆子(Brucea javanica)种子的甲醇提取物中分离和鉴别得到11个化合物,经波谱数据分析分别鉴定为鸦胆子内酯A(1),鸦胆子素D(2),鸦胆子苷A(3),C(4),F(5),G(6),L(7),3β-羟基-孕甾-5-烯-20-酮(8),3β-羟基-5α-孕甾-20-酮(9),3-O-β-D-吡喃葡萄糖基-(1→2)-α-L-吡喃阿拉伯糖基-(20R)-孕甾-5-烯-3β,20-二醇(10)和6,22-二烯-3β-羟基5,8-过氧麦角甾(11)。其中化合物8、9和11为首次从该植物中分离得到。鸦胆子内酯A(1)和鸦胆子素D(2)对人类癌细胞株BGC-823,Huh-7,KE-97和Jurkat具有很好的细胞毒作用。
Eleven compounds were isolated and identified from the methanol extract of Brucea javanica seeds and identified as Brucine javanicae A (1), Brucein D (2), Brucein A ( 3-C (4) F (5) G (6) L (7) 3β-hydroxy- 3-O-β-D-glucopyranosyl- (1 → 2) -α-L-arabinopyranosyl- (20R) -pregn-5-ene-3β, 20 - diol (10) and 6,22-diene-3 [beta] -hydroxy 5,8-oleyptrenol (11). Among them, compounds 8, 9 and 11 were isolated from this plant for the first time. Brucein A (1) and Brucein D (2) have good cytotoxic effects on human cancer cell lines BGC-823, Huh-7, KE-97 and Jurkat.